BioStacks
Best for
Ingredients (3)
EpiCor dried yeast fermentate
100%Dose
630 mg
Target
500–500 mg
Form
—
Bluenesse Lemon balm extract
100%Dose
300 mg
Target
300–600 mg
Form
—
Adonat SAM-e (S-Adenosyl-L-Methionine)
13%Dose
100 mg
Target
800–1600 mg
Form
Not listed
Other Ingredients (6)
Rice ExtractFiller
Rice-based ingredients carry risk of inorganic arsenic contamination. Vague labeling — 'rice extract' does not specify what is extracted or standardized. Used as a cheap filler with no supplemental benefit.
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
HypromelloseCapsule
Plant-derived capsule material from cellulose
Sunflower Seed OilCarrier
Common vegetable oil from sunflower seeds used as a carrier in softgels for fat-soluble nutrients
Vegetable/Confectioner's Glaze & WaxCoating
Plant-derived glaze or wax used as a tablet coating/polish.
How to Take It
Check the label before you take this
This product combines a stimulant with a sleep-supporting ingredient, so there's no single good time to take it. Follow the label and keep it well away from bedtime.
On an empty stomach
Space it a couple of hours from 5-HTP
On the label
Take 2 capsules daily with food.
Labels usually say “with food” because it's gentler on the stomach, not because it absorbs better. Fasted absorbs more — start there, and switch to a light meal if it bothers you.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$46.99
Near the median of 24 SAMe supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.