BioStacks

Best Apigenin for Sleep

Top 7 products ranked

Last reviewed May 2026

Clinical dose: 50–200 mg

Why Apigenin for Sleep

Apigenin plays a supporting role in sleep. Apigenin is a flavonoid found in chamomile that acts as a mild GABA-A receptor ligand. Clinical evidence is almost entirely for chamomile extract, not isolated apigenin. In clinical studies, apigenin may support sleep quality through mild sedative effects.

What dose to look for

Clinical studies typically use 50–200 mg of apigenin. 50 mg isolated apigenin is the popular protocol; clinical evidence is primarily for chamomile extract (500-1500 mg, which delivers ~5-15 mg apigenin). Products below this range may not deliver meaningful results.

What the research says

Apigenin has limited clinical evidence for sleep benefits. No clinical trials for isolated apigenin at supplement doses; evidence is for chamomile extract only Learn more

Clinical research on Apigenin / Chamomile

LOW-MODERATE — Trending ingredient, limited human data · 50 mg isolated apigenin OR 500–1,500 mg chamomile extract

•2024 meta-analysis of chamomile trials found improved sleep quality (particularly night awakenings), but did NOT improve sleep duration or efficiency.
•Chamomile extract (1,500 mg/day) significantly reduced anxiety in GAD patients in multiple RCTs. Sleep benefits may be secondary to anxiolysis.
•Acts as a benzodiazepine-receptor ligand on GABA-A receptors, producing mild sedative and anxiolytic effects.
•Popularized by Andrew Huberman at 50 mg, but no RCTs exist for isolated apigenin at that dose for sleep. Clinical evidence is for chamomile extract (~1% apigenin).

See full Sleep research →