BioStacks
Best for
Ingredients (7)
Vitamin B12
100%Dose
500 mcg
Target
250–5000 mcg
Form
Premium
Vitamin B6
100%Dose
2 mg
Target
1.3–25 mg
Form
Premium
L-5-Methylfolate calcium salt
50%Dose
200 mcg
Target
400–800 mcg
Form
Premium
Folate
83%Dose
333 mcg DFE
Target
400–800 mcg
Form
Not listed
SAMe
25%Dose
200 mg
Target
800–1600 mg
Form
Standard
Other Ingredients (3)
Gellan GumGelling Agent
Microbial polysaccharide produced by Sphingomonas elodea, used as a gelling and stabilizing agent
LeucineFlow Aid
Branched-chain amino acid used as a processing aid
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
How to Take It
Best taken in the morning
Contains SAMe, which is stimulating — keep it to the morning. What's in this is easier on the stomach taken with food.
With food
SAMe does better on an empty stomach, but something else in this bottle needs food. Taking the whole product with a meal is the better trade — an upset stomach is why most people stop.
Keep it away from high-oxalate foods like spinach
Space it a couple of hours from Iron, Zinc and 5-HTP
On the label
One to two (1-2) capsules daily, between meals, or as directed by a healthcare professional.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$72.50
Pricier than 74% of 24 SAMe supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.